Our lab studies fundamental aspects of cellular mechanobiology, i.e., how cells sense the mechanical features of the extracellular matrix, and how these features affect cellular behavior under normal and disease conditions. 

We are currently setting up the lab and we are looking for a lab manager and talented MSc and PhD students. Please contact us at: haguyw@technion.ac.il

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Cells sense the mechanical features of the extracellular matrix by applying forces to it through integrin adhesions. This process (termed ‘mechanosensing’) occurs on short time- and length-scales, but it affects global cellular functions that occur on timescales of hours-to-days. In the lab, we are studying how the mechanical signals are transmitted to affect cellular decisions under normal conditions, and how this process is altered in cancer cells which effectively ignore the mechanical properties of the matrix. (read more…)